Metabolism

Intermittent schedules, exercise timing, and the mixture of animal research, mechanistic reasoning, and repetition that shaped today's community conventions.

NAD+ sits at the center of how cells make energy and repair themselves, and it appears to fall with age. That has made raising it one of the most pursued ideas in longevity — and one of the most instructive tests of how biology translates from mice to people.

By engaging three metabolic receptors at once — GLP-1, GIP, and glucagon — retatrutide represents a genuinely new idea in metabolic pharmacology. Here is what triple agonism means, and what the human data shows so far.

Mitochondria do far more than make energy — and their gradual dysfunction sits close to the center of why bodies age. A guide to the biology that has made mitochondria one of the most important targets in longevity research.

A tiny peptide encoded inside the mitochondria may help explain how our cells adapt to exercise and metabolic stress — and it is opening a fascinating window into the biology of aging.